HSA 535 WK10 DB1 and DB2 Coursework Example | Topics and Well Written Essays - 500 words

HSA 535 WK10 DB1 and DB2 - Coursework Example Although the causes of the infant’s deaths from SID have not yet been established, there is clear need of creating awareness to the mothers. The young mothers need to ensure that they take care of the sleeping positions of the infants so that do not cause their deaths. Additionally, young mothers should be taught on how to talk care of their children, especially when they are sleeping on the baby cots, because that is where many infant deaths occur (Fowler et al., 2013). Therefore, to reduce the alarming rate of deaths caused by SID, mothers should be informed on the ways to lay their babies while they sleep the right food to eat while pregnant to avoid low birth weights and keeping the babies warm to avoid respiratory infections. Fowler, A. J., Evans, P. W., Etchegaray, J. M., Ottenbacher, A., & Arnold, C. (2013). Safe Sleep Practices and Sudden Infant Death Syndrome Risk Reduction NICU and Well-Baby Nursery Graduates. Clinical pediatrics, 52(11), 1044-1053. Your post was very informative and I agree with your point of view, because childhood obesity is not only a problem in Georgia, but also the whole of the United States. Lack of physical education in school and at home has contributed greatly to the increased number of children with obesity in Georgia. Therefore, making it important for the schools to change the nutrition program and increase physical activity to reduce the number of obese children. I agree with you on the focus of health services management should be and that is the on the health population they serve and not on the fiscal health of the institutions. This means we need a change of agents in the health care system in relation to aligning economic and social objectives to allow the improvement of population health. This course has been informative and there are various concepts that I have learned. First, there is need for creation of awareness in areas that are causing

Oral Fast Disintegrating Anti-allergic Film Using Hot-melt

Oral Fast Disintegrating Anti-allergic Film Using Hot-melt Development and Evaluation of an Oral Fast Disintegrating Anti-allergic Film Using Hot-melt Extrusion Technology Manjeet B. Pimparade1, Anh Vo1, Abhijeet S. Maurya1, Joseph T. Morott1, Xin Feng1, Dong Wuk Kim1, Vijay I. Kulkarni1, Roshan Tiwari1, K. Vanaja2, Reena. Murthy2, H. N. Shivakumar2, D. Neupane3, S. R. Mishra3, S. N. Murthy1, Michael. A. Repka1,4* 1Department of Pharmaceutics Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA 2Institute for Drug Delivery and Biomedical Research, Bangalore, India 3Department of Physics, University of Memphis, Memphis, TN, USA 4Pii Center for Pharmaceutical Technology, The University of Mississippi, University, MS, USA *Address for correspondence: Michael A. Repka, D.D.S., Ph.D. Professor and Chair, Department of Pharmaceutics and Drug Delivery Director, Pii Center for Pharmaceutical Technology School of Pharmacy The University of Mississippi, University, MS 38677 Abstract The main objective of this novel study was to develop chlorpheniramine maleate orally disintegrating films (ODF) using hot-melt extrusion technology and evaluate the characteristics of the formulation using in vitro and in vivo methods. Modified starch with glycerol was used as a polymer matrix for melt extrusion. Sweetening and saliva-simulating agents were incorporated to improve palatability and lower the disintegration time of film formulations. A standard screw configuration was applied, and the last zone of the barrel was opened to discharge water vapors, which helped to manufacture non-sticky, clear, and uniform films. The film formulations demonstrated rapid disintegration times (6-11 s) and more than 95% dissolution in 5 min. In addition, the films had characteristic mechanical properties that were helpful in handling and storage. An animal model was employed to determine the taste masking of melt-extruded films. The lead film formulation was subjected to a human panel for e valuation of extent of taste masking and disintegration. Keyword: Hot-melt extrusion, Orally disintegrating film, Taste-masking, Pediatric and geriatric, Modified starch, Human panel taste evaluation, Continuous manufacturing, Chlorpheniramine maleate Introduction It is estimated that 26-50% of the patient population find difficulty in swallowing tablets and hard gelatin capsules [1]. These patients mainly include the elderly who have difficulty taking conventional oral dosage forms because of hand tremors and dysphagia, and pediatric patients who are often fearful of taking solid oral dosage forms owing to their underdeveloped muscular and nervous systems [2]. In addition, patients who are mentally ill, developmentally disabled, uncooperative, on reduced liquid-intake plans or nauseated, and travelers who may not have access to clean water also are candidates for ODFs [3, 4]. The traditional alternative to swallowing difficulties is formulating a drug substance in liquid dosage form. However, liquid dosage forms have several limitations, such as the need for measuring, bulkiness, physical, chemical, and microbial stability issues, spoilage, inaccurate dosing, and organoleptic properties of drug and drug formulations [5]. Conventional solid oral formulations contributed significantly to minimizing the shortcomings of liquid dosage forms. The crushing of tablets or opening of capsules is a straightforward way for patients or caregivers to lessen the swallowing difficulties. However, serious consequences may be associated with modified-release, enteric-coated, and cytotoxic or hormonal medicines, as these formulations are designed for special cases [6]. Moreover, European Medical Agency does not recommend the splitting or crushing of tablets because the active pharmaceutical ingredient (API) is not evenly distributed in the tablet [7, 8]. Thus, it is very convenient to develop a formulation that disintegrates in the oral cavity and eases the swallowing process. In recent years, fast disintegrating oral formulations established their importance in patient population suffering from dysphagia, stroke, thyroid disorder, Parkinsons disease, multiple sclerosis, and cerebral palsy [9]. Commercially available orodispersible tablets (ODT) and orodispersible films (ODF) are the most successful platforms for pharmaceutical product development. ODTs are solid oral dosage forms that disintegrate rapidly, typically within 30 s, with or without the administration of additional water [10]. They provided great comfort to patients with swallowing difficulties [11]. Despite the benefits of ODTs, there are some challenges in their processing and handling owing to their fragility and brittleness, which warrant special package for protection during storage and transportation [12]. The films are flexible and not as fragile as most ODTs. Hence, there is ease in transportation, consumer handling, and storage of ODFs. ODF can be defined as a dosage form that employs a water-soluble polymer (generally a hydrocolloid, which may be a bioadhesive polymer), which allows the dosage form to quickly wet, adhere, and dissolve to release the drug when placed on the tongue or in the oral cavity [5]. ODF alleviated patient discomforts associated with swallowing disabilities without compromising the therapeutic effect. In addition, it could ease the administration of drugs to pediatric patient population [13]. Moreover, ODF can be helpful in curtailing dose variations in younger patients, in whom liquid formulations are the most accepted way of drug delivery. Currently, solvent casting methods are commonly employed to produce ODFs, owing to its ease of production and low set up costs [14, 15]. Despite its wide application, products with batch-to-batch variation may be produced because of multiple steps involved in the production. In addition, air entrapment in the films is commonly observed in solvent casting methods, which leads to dose variations and inappropriate esthetic appearance of the product [15]. The use of large amounts of solvent is one of the biggest shortcomings of this method as solvent removal and disposal is a long and tedious process. Thus, it is very beneficial to develop a solvent-free, quick, and continuous process that could diminish the shortcomings of the current manufacturing method. Hot melt extrusion (HME) is a one-step, solvent-free continuous manufacturing process, which established itself in the pharmaceutical arena for the development of various solid oral formulations [16-25]. This technology involves the use of temperature and shear to process polymer blends and extrude them through a die of the desired design [26]. HME could be an effective alternative to the solvent casting method as it diminishes the inherent shortcomings, such as the use of solvents and problems involved in the mixing and drying steps. This ultimately makes HME process efficient and cost effective for patients [27, 28]. This study has three main objectives: to 1) develop a robust patient-friendly orally fast disintegrating film of chlorpheniramine maleate (CPM); 2) evaluate these formulations with different in vitro and in vivo techniques, and 3) demonstrate the feasibility of HME techniques for continuous manufacturing of ODF without the use of solvents. To the best of our knowledge, there is no published literature on the manufacturing of orally fast disintegrating formulations using HME technology and evaluation of films using in vitro and in vivo techniques. Materials and Methods 2.1. Materials CPM was purchased from MP Biomedicals, LLC (Solon, OH, USA). Lycoat RS 780 (modified starch) was supplied by Roquette America Inc. (Keokuk, IA, USA). Citric acid and glycerol were ordered from Fisher Scientific (Pittsburgh PA, USA). Magnasweet sample was gifted by Mafco worldwide LLC (Camden, NJ, USA). Sucralose was supplied by JK Sucralose Inc. (Edison, New Jersey, USA). 2.2. Thermal analysis Thermogravimetric analysis (TGA) studies (Perkin Elmer Pyris 1, Shelton, CT, USA) were performed to estimate the thermal stability of the API and excipients during HME processing. Data were analyzed using Pyris software. The API excipients were heated from 30-160à ¢Ã¢â‚¬Å¾Ã†â€™ at 20à ¢Ã¢â‚¬Å¾Ã†â€™ /min. 2.3. Material preparation and blending CPM, citric acid, and Lycoat RS 780 were dry mixed at amounts outlined in Table 1 using a V-shell blender (GlobePharma, Maxiblend, New Brunswick, NJ, USA) after passing through an ASTM #30 mesh. The plasticizer (glycerol with dissolved sucralose and Magnasweet) was incorporated slowly into a high-shear mixer (Model RSI 3VG, Robot Coupe Industrial Division, Ridgeland, MS, USA) containing the previously mixed blend with all excipients and allowed to blend for 10 min. 2.4. Hot melt extrusion The blends were melt-extruded using a co-rotating twin-screw extruder (16 mm Prism EuroLab, ThermoFisher Scientific, Pittsburgh, PA, USA) at 30-50 rpm over a temperature range of 100-  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚  Ãƒâ€šÃ‚   110à ¢Ã¢â‚¬Å¾Ã†â€™. A degassing port was introduced in the last zone of the barrel to release excess water vapor, which would otherwise produce unwanted bubbles in the films. Additionally, the film die was installed with preset thickness. The physical blend of the formulation was manually fed into the hopper, and the films were collected, wrapped in wax paper, sealed, and stored in polyethylene bags at 25à ¢Ã¢â‚¬Å¾Ã†â€™ with 40% relative humidity. 2.5. Film characterizations 2.5.1 Film thickness and mechanical properties The mechanical properties of the films were evaluated using the TA.XTPlus texture analyzer equipped with 5 kg load cell (Texture Technologies, Scarsdale, NY, USA). The films were cut into dumbbell shaped specimens with a width and length of 1.55 and 15.5 mm, respectively, and placed longitudinally in tensile grip probe on the texture analyzer. The films were tested at a crosshead speed of 2 mm/min and held between two clamps positioned at 5 mm. The results of film samples that broke at and not between the clamps were not included in the calculations. Each film formulation was measured with ten replicates [29]. The tensile strength (Ts) and percent elongation (%E) were calculated using the results from texture analyzer. Film thickness was measured using an electronic caliper (Fisher Scientific, Pittsburgh, PA, USA) at different positions. 2.5.2 Disintegration test The film was cut into an appropriate size as per the dose (4 mg) and placed in a petri dish. Then, 100  µL artificial salivary media was added, and the time for complete disintegration of the film was recorded (n =10). 2.5.3 Surface pH of film The film was moistened using 5  µL water and a contact electrode touched the surface of the film (Oaktonà ¢Ã¢â‚¬Å¾Ã‚ ¢ pH meter, Fisher Scientific, Pittsburgh, PA, USA), followed by pH measurement (n=6) 2.6. Analytical method A Waters high performance liquid chromatography (HPLC) system equipped with a Water 600 binary pump, Waters 2489 UV/detector, and Waters ® 717 plus autosampler (Waters Technologies Corporation, Milford, MA, USA), and a Phenomenex Luna 5  µm C18 (2) 250 x 4.6 mm column (Torrance, CA, USA) were used at a detection wavelength of 254 nm. The mobile phase consisted of 7.5 mM monobasic potassium phosphate in methanol and water at a ratio of 62.5:37.5 (v/v). The mobile phase flow rate was maintained at 1.0 mL/min, and an injection volume of 10 ÃŽÂ ¼L was used [30]. HPLC data were analyzed using Empower 2 software (Milford, MA, USA). 2.7. In vitro dissolution studies The films for dissolution studies were cut into sizes relative to the dose of CPM (4 mg). The drug profile was evaluated using a USP dissolution apparatus-I (Hanson SR8, Chatsworth, CA) maintained at 37  ± 0.5à ¢Ã¢â‚¬Å¾Ã†â€™ and having a shaft rotation speed of 100 rpm. The dissolution test was performed using 900 mL phosphate buffer (pH 6.8). The samples were withdrawn at 5, 10, and 30 min and analyzed using the HPLC- UV system. 2.8. X-ray diffraction studies (XRD) X-Ray diffraction (Bruker D8 Advance, Madison, MI, USA) was used to determine the physical state of the drug, excipients, and film formulations. The X-ray diffraction apparatus used CuK radiation at 40 mA, 40 kV, a scanning speed of 2à ¢- ¦/min, and diffraction angle (2ÃŽÂ ¸) range of 5-55. 2.9. Scanning electron Microscope (SEM) The surface morphology of the films was evaluated using SEM analysis. The samples were mounted on adhesive carbon pads placed on aluminum and sputter coated with gold using a Hummer sputtering system (Anatech Ltd, Springfield, VA, USA) in a high vacuum evaporator. A JEOL JSM-5600 SEM operating at an accelerating voltage of 10 kV was used for imaging. 2.10. In vivo taste evaluation Twenty-one naÃÆ' ¯ve adult male Sprague-Dawley rats (175-200 g) were ordered from Harlan Laboratories (Houston, TX, USA) for the study. The rats were housed in Plexiglass cages with Corncob bedding in a vivarium that maintained a 12 h light/dark cycle and an ambient temperature of ~22à ¢Ã¢â‚¬Å¾Ã†â€™. Food and water were available without any restriction, except during the training and taste evaluation experiments as mentioned below (2.10.1). All procedures were approved by the Institutional Animal Care and Use Committee (IACUC) at The University of Mississippi, University, USA (protocol no. 15-026). This study was performed as per the procedure in our previous publication on taste assessment method for bitter drugs [31]. 2.10.1. Training paradigm The rats were trained for licking behavior (response to thirst) by depriving them of water for 22 h, but they had ad libitum access to food. After the water deprivation period, the Plexiglass cage was divided using plastic transparent dividers to provide an individual water bottle to each animal. Eventually, the rats were provided with graduated water bottle for 30 min, and the amount consumed at 15 and 30 min were recorded. This training paradigm was performed for 2 days before the taste evaluation experiment. 2.10.2. Evaluation of bitterness sensitivity of rats To determine the concentration of CPM for this study, a sensitivity test for bitterness was performed in rats. After depriving the rats of water for 22 h, sensitivity toward 0.5 mg/mL CPM solution was evaluated on the first day, followed by a washout period of 24 h. Subsequently, the effect of 1 mg/mL CPM solution was examined, and the results were recorded. 2.10.3. Experiment The experiment was performed for 30 min with 30 mL test formulation following the 22 h water deprivation period. After each experiment, the rats had a washout period of 24 h to avoid any memory of the taste of the previous formulation. The rats had ad libitum access to food during the experiment and washout period. The amount of solution remaining at 15 and 30 min was noted and subtracted from the original test volume. Varying results caused by spilling of the test solution while measuring or leaking of bottle knob were omitted from the study. Notably, animal behavior responses such as jaw smacking, oral grooming, and retreating were observed, which was not the focus of this study. Formulations N2, N7, and N9 at 0.5 mg/mL CPM were used for bitterness evaluation study in rat model. The average amount of solution consumed by all animals was calculated and expressed as the mean standard deviation. The mean scores between the physical mixture and formulation were compared using a student t-test at 95% confidence level and P 2.11. Film evaluation by human panel The evaluation of film for palatability, disintegration time (DT), and organoleptic characteristics was performed at the Institute for Drug Delivery and Biomedical Research, Bangalore India (Protocol number VIPS/2013/12). The subjects were recruited after obtaining informed consent. This study is also in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki). The experimental procedure for this study was as per our previously published work [10, 32]. 2.11.1. Human subject selection criteria Six human subjects belonging to either sex were recruited. They were asked to abstain from coffee/tea and other beverages for 12 h. The subjects were allowed to drink only water for 12 h. Moreover, they were asked not to eat chocolates or other candies for over 6 h. The inclusion criterion was healthy human subjects aged 18-42 years, and the exclusion criteria were subjects suffering from fever, mouth ulcers, dry mouth, cold, nose block, and wounds as well as smokers.   2.11.2. Data collection Before data collection, the subjects were asked to wash their mouth with water at ambient temperature. The surface temperature of the tongue was recorded using an infrared (IR) thermometer, and a difference of  ±5à ¢Ã¢â‚¬Å¾Ã†â€™ relative to the body temperature was considered an exclusion criteria. 2.11.2.1. Bitterness perception The subjects were asked to taste aqueous solutions of CPM, beginning with very dilute solutions and progressing to higher concentrations, by placing 2 mL solution for 30 s on the tongue/buccal cavity. The concentrations screened were 0, 0.5, 1, 2.5, and 4 mg. The volunteers were asked to report the perception each time: 1- I feel bitter taste, 2- I feel something but cannot identify the taste, and 3-I do not feel the taste. The subjects who reported 2 or 3 were asked to taste higher concentrations of the solution until they expressed perception 1. This was recorded as the threshold for an individual. For individuals who reported a score of 1, at least 1/5th the drug concentration of the actual dose was only allowed for testing the products. A few high concentration API solutions above the individuals perception threshold were made for tasting, and the subjects were subsequently asked to provide a score for each solution (Table 3). The highest concentration of the solution contained C PM equivalent to the dose present in the products tested. The scoring pattern followed was according to modified hedonic scale: 0-no taste, 1- taste something (threshold), 2-slightly bitter, 3-moderately bitter, 4-bitter, and 5-strongly bitter. 2.11.2.2. Formulation evaluation and data analysis A washout interval of 12-24 h was allowed after screening the standard solution. The individuals were asked to taste the products (physical mixture or ODF) randomly (blinded) and score the product. The products were placed on the tongue/buccal cavity for 30-40 s, and the subjects were asked to score the bitterness on a scale of 0-5 for each product. Moreover, volunteers were asked to report the time for complete disintegration of the film. Sufficient washout time was allowed between the products, and the volunteers were allowed to drink copious amounts of water after tasting each product. The average of the scores given by all individuals were taken and expressed as the mean standard deviation. The mean scores between the physical mixture and formulation were compared using a student t-test at 95% confidence level, and P Results and Discussion 3.1. Preparation of hot-melt extruded film Modified starch is very difficult to extrude because of its high glass transition temperature. Thus, there is a need to introduce a plasticizer during extrusion, which could reduce the melt viscosity and increase the free volume of starch chains. For this study, glycerin was used as a plasticizer in different proportions, and it exhibited excellent extrudability with significantly lower torque (4.8-7.2 Nm) values than typically encountered. The barrel design was modified with a degassing port to remove excess amount of water vapor from the molten mass. Initial studies without a degassing port demonstrated the presence of bubbles as well as unequal distribution of drug in the film samples. Standard screw configuration (Figure 1) with three mixing zones was utilized for this study. It provided enough shear for dispersive and distributive mixing of the drug and helped get excellent content uniformity in all the extruded film formulations. The extruded films were stretched using the roll connected to the extruder assembly. This aided in making thin films with uniform thickness, and the roll speed was optimized for steady collection of the film. The combination of processing and formulation parameters helped to manufacture uniform, clear, and very thin films (60-110  µm) using melt extruder. 3.2. Physiochemical evaluation of films TGA is very critical before performing HME because the drug and excipients are exposed to high temperature during the extrusion process, and there are possibilities of drug degradation or thermally-induced chemical reactions or both [16]. The TGA results (Figure 2) specified that API, polymer, and excipients were chemically stable in the HME processing temperature range. Lycoat RS 780 demonstrated a loss of weight (33]. XRD was used to investigate the physical state of the drug after HME process. The XRD results (Figure 3a 3b) of CPM illustrated prominent peaks at 2ÃŽÂ ¸ angles of approximately 13, 19, and 20 degrees, while citric acid showed peaks at 2ÃŽÂ ¸ angles of 18, 19, and 26. The melt-extruded formulation did not show any peak that confirmed the presence of drug in an amorphous form. The reasons behind the complete conversion of drug to an amorphous form were the high shear during extrusion, low drug load, and relatively high amounts of glycerin. The presence of CPM and excipients in an amorphous form aided the flexibility and clear appearance of the film. 3.3. Dissolution studies Lycoat RS 780 is a comparatively new modified starch-based polymer, which demonstrated its significance in film coating for tablets and oral film development using solvent casting method [34, 35]. Being a non-gelling and highly water-soluble polymer, it provides rapid disintegration and dissolution to formulations. Visual inspection during dissolution demonstrated rapid disintegration of the film when it touched the dissolution media. This characteristic helps in the rapid onset of action of the formulation, because the drug can diffuse from the oral mucosa and reach the systemic circulation [36]. During dissolution studies, the formulations rapidly release CPM, and it was attributed to hydrophilic excipients and Biopharmaceutics Classification System (BCS) class I drug. These films had very low thickness (60-110  µm) and higher surface area, which enabled interaction with dissolution media and rapid disintegration following complete dissolution. Dissolution results (Figure 4a 4b) showed ~95% drug release in the first 5 min of the dissolution experiment, and at 10-min time points, there was complete release of the drug. 3.4. SEM evaluation The surface morphology was examined by SEM for all film formulations. SEM images did not exhibit CPM crystals, indicating an amorphous nature of drug in formulations (Figure 5). The formulations showed very smooth surface at low magnification. This affirmed the smooth texture of film surface, which is one of the esthetic attributes of films. However, at microscopic level, there was high surface area, which helped in the rapid disintegration of the film. 3.5. Film characterizations As illustrated in Table 2, the film formulations demonstrated excellent D.T of 6-11 s, which was attributed to the thickness of the film and presence of water-soluble materials in the film. The formulations contained water-soluble excipients and APIs such as CPM, citric acid, glycerin, and modified starch. The most crucial parameter for disintegration is the low thickness of the film. As the films had a thickness range of 60-110  µm, they aided in the faster disintegration of all film formulations. In addition to the low thickness of the film, the amount of saliva in the oral cavity is very critical for rapid disintegration. The normal flow of saliva in a healthy person is 0.34 mL/min, and it can be increased by the addition of agents that simulate salivary production, including citric, malic, lactic, ascorbic, and tartaric acids [14]. Citric acid is the most preferred saliva-stimulating agent, and it was estimated that citric acid could increase salivary flow approximately 5- fold in 2-6% proportion in the formulation [14]. With the addition of citric acid, the pH of the films was found to be in the range of 2.9-3.4 and it could contribute in improving rate of salivary flow after administration of formulation which will aid in rapid disintegration of film product. All the film formulations were tested for their Ts and %E (Table 2). Ideally, the film should have desirable mechanical properties so that it can remain intact during handling and transport. ODFs showed appropriate strength and %E. These excellent mechanical properties were attributed to the presence of glycerol, citric acid, and CPM, which reduced film stiffness via disruption of intermolecular forces of the polymer owing to the accommodation of these compounds between the strands, thereby providing elasticity to the films [37, 38]. 3.6. In vivo taste evolution Firstly, the taste perception of rats was evaluated by administering 0.5 and 1 mg/mL CPM dissolved in distilled water. These results were important to avoid taste variability between animals (Figure 6), and showed that the rats consumed ~10 and ~14 mL of water in 15 and 30 min, respectively. The results of this study were comparable with those of the study published by Tiwari et.al. Thus, the rate and extent of consumption of water were reduced significantly to ~3 and ~5 mL in 15 and 30 min with the administration of 0.5 mg/mL CPM solution. At a higher concentration of 1 mg/mL, there was notable reduction in consumption of water to ~1.6 and ~2 mL at 15 and 30 min. Notably, this reduction in consumption of CPM solution despite deprivation of water for 22 h affirmed an aversion toward CPM. Moreover, aversion behaviors (Figure 7), such as jaw smacking, oral grooming, nose wrinkle, paw wipe, forelimb flail, head shake, paw shakes, and retreating confirmed the dislike of rats toward the d rug solution [39]. As illustrated in Figure 6, the rats consumed ~10 and 12.5 mL of N 2 solution (5% CPM in the film) in the first 15 and 30 min, and the amount was comparable with the consumption of water. In addition, N7 (10% CPM) exhibited consumption of ~ 4.7 and ~8 mL at 15 and 30 min. Furthermore, N9 (7.5% CPM) showed consumption of ~6.3 and 10 mL at 15- and 30-min time point. These results indicated that with increasing concentrations of CPM, there was noticeable reduction in the consumption of formulation. The rats did not show aversion behavior such as forelimb flail with N2 formulation. However, there was a surge in the aversion behavior response upon increasing the drug concentrations in N7 and N9,. The results of this study were very helpful to understand about the taste of pure drug and formulation. It provided an insight into the taste of products, which helped to screen this formulation for human studies. 3.7. Film evaluation by human panel Before evaluation of taste of the formulation, it is very important to understand the taste perception of human volunteers to minimize intra-subject variability. Taste perception study was performed on six healthy human volunteers. Initially, different concentrations of CPM in 2 mL of water were administered to the human subjects. Three subjects had threshold at 0.5 mg and the remaining three subjects reported moderate bitterness at the same concentration. A dose of 2.5 mg demonstrated bitterness in all subjects, and only three volunteers could taste higher concentration of CPM (4 mg, Table 3). This initial evaluation confirmed the appropriateness of the subjects for taste masking study. The results of taste masking evaluation in animal model suggested that formulation N2 with 5% CPM had significant taste masking. Moreover, this formulation had an excellent D.T (7 s) in in vitro studies. Based on t

Student Diversity :: essays papers

Student Diversity Teachers are forced to deal with several different types of students every day, throughout their careers. Some children live in poverty, some have disabilities, some of different races and ethnicities that are all accumulated in one classroom. These children may be harassed by other children in the classroom because they are different from the majority of the other students. Teachers must recognize these problems and do everything in their power to make these students feel equal. Statistics show that more than one out of every five students in the U.S. live in poverty. This is one of the reasons that children face problems academically. Nearly one quarter of students in the classroom live below the level of poverty. Children do not understand that it is not the choice of a child to live this way, and therefore criticize them for this difference. Teachers must realize this and do everything in their power to teach students that diversity will be found everywhere, not only in the classroom. Teachers must realize that these children expect less of themselves, and therefore try harder to make them welcome in the classroom and the learning environment. Other children carry the burden of physical or mental disabilities. These children are entitled to the same educational opportunities as children without these handicaps. Special education programs were devised to give these students a better environment in which to learn. This provides extra help in the areas that it is needed in, and teachers with proper training in the teaching of the disabled student. Soon, these students may be taken out of separate classrooms and incorporated into the classrooms with other students. Teachers must be prepared to handle this diversity and make the learning environment conducive to their learning without slowing down other students. Teachers also experience a variety of races and ethnicities in their classrooms. Even though a student may be of a different race, or belong to a minority, it is important to treat these children in the same way that one would treat any other student.

Samson and delillah

The following case study is an exploration of the Australian film Samson and Delilah which features the impact that the volatile substance abuse [VSA] of petrol sniffing has on one of the characters in the film, Samson. I have chosen him to be the basis for my client and case-study and will begin by giving a description of the character, his family life and the social context to start this case-study. I will then provide an assessment and case formulation as well as Samson's psychosocial needs and his volatile substance abuse of petrol sniffing.The substance abuse counselling model hat I would draw on is explained, as well as the usefulness for Samson in the situation that he is in. I have explained the way in which I would work with Samson and also analysed research that is relevant to Samson's dependence on sniffing petrol and discussed any likely outcomes. In concluding this case-study I have listed any challenges that I feel he would face and identified any ethical issues that ma y arise. Background Information Samson is a 14 year old Indigenous Australian male who lives in a remote Aboriginal Community in the central Australian desert.Samson lives with his rothers who hang out in their run down shack, playing music from the moment that they wake up until the moment that they go to sleep. When Samson wakes up in the morning the first thing that he reaches for is his canister of petrol and starts sniffing the fumes that enable him to get high. Samson doesn't go to school or have any direction in life, he seems to be very bored and spends his days hanging around the community, doing nothing but getting high on petrol fumes.Samson runs away from the community with his girlfriend Delilah after Samson has a violent fight with his rother and Delilah is attacked by the older women after her beloved grandmother dies. They go to the city where they camp out under a bridge, they have no money and in order to eat, and have to rely on a homeless man that they meet to fe ed them or steal food from the local supermarket. Delilah is kidnapped as they are both walking along which Samson is oblivious too as he is so high on petrol fumes.His girlfriend is raped and bashed by the abductors, but when she returns back to the camp Samson is unconscious on the ground, passed out from sniffing petrol. Delilah tarts sniffing petrol as well and is hit by a car as they are walking along the road, which Samson is once more oblivious too, as they are both high on petrol fumes. Delilah recovers in hospital, comes back and takes Samson to a remote property where she intends on helping him to dry out, but finds him sniffing petrol again. Assessment of Samson Samson has been heavily abusing this volatile substance to the point where he is physiologically dependent on sniffing petrol .Behave Net(2013) explain that substance dependence can be diagnosed when an individual continues to use the rug, even though there are problems associated with the use of the volatile subs tance. Samson has built up a tolerance to the petrol and seems to need increased amounts of this substance in order to attain the desired level of intoxication. Rassool (2009) confirms this, stating that when a body adjusts to the habitual use ot a drug, tolerance occurs as higher doses ot the substance are needed to â€Å"reproduce the desired or similar cognitive, affective or behavioural effects† (p. ). Petrol sniffing is a form of volatile solvent abuse [VSA] that is more common in isadvantaged or isolated communities which reflects the history of cultural oppression, poor health, unemployment, recreational opportunity and geographical isolation of remote Indigenous Australians( Dingwall, Lewis,Maruff ; Cairney 2010). Research has shown that 14 to 17 year old Indigenous Australian males are more habitual in the use of VSA by using more frequently and longer than non- Indigenous users (Australian Government Department of Health and Aging Publications, 2004).High risk behav iours are associated with VSA due to the individual feeling a sense of eing invulnerable, which can cause accidents, injury and death (Cairney; Dingwall, 2010). VSA can also cause the individual to have violent outbursts towards other individuals as well as showing signs of slurred speech, confusion and stupor which can lead to seizures, brain injury and death (Australian Government Department of Health and Aging Publications, 2004).Samson is showing all the signs of chronic use of VSA in relation to his oblivion of all of the trauma that has resulted from his dependence on petrol. I feel that Samson is bored because of the lack of recreational ctivities as well as schooling, there also does not appear to be any cultural programs in place to guide him in helping him with a sense of identity, or any real family support including the sharing of the cultural knowledge of elders.Intervention Plan Although there are screening tools such as The Indigenous Risk Impact Screen and Brief Inte rvention Tool Kit (Amity Community Services, n. d), I feel that the best approach in helping Samson and his dependence on VSA, is to consult with community elders as he is not only a minor, but there are also a lot of cultural arriers that would make it very difficult to counsell him unless the person were specially trained. It would be especially difficult as Samson speaks his traditional language and very little English.Cairney and Dingwall (2010) find that it is hard for the problem of VSA to be managed and the impact of it to be understood by Indigenous communities as well as health and government services because of the severe cultural differences that occur between these groups. Aboriginal people have a kinship structure where immediate and extended family are seen as part of the roup and within Indigenous communities their health is seen as a collective of the emotional, social and cultural wellbeing of the community (Pattel, 2007).I have personally never worked with clients with VSA, but I feel that motivational interviewing would also benefit Samson's brothers and their community in helping them overcome the problems of VSA. Giddens-Tracey (2005) explains that motivational interviewing is non -Judgmental and avoids confrontation, it helps to raise awareness of the problems, risks and consequences as a result of certain ehaviours, and it is also helpful in the context of treatment planning.MacLean and d'Abbs (2002) also believe that the introduction of Youth focused programs and the accessibility of basic food, shelter and education would reduce petrol sniffing, which would greatly benefit Samson if these projects were to be put in place. Cairney and Dingwall (2010) also suggest that by replacing the volatile petrol with a non-volatile fuel derivative there will be a reduction in the supply of petrol to inhale. Treatment Process I believe that the first step that would need to be taken in the process ot treatingSamson is to have a doctor or health prac titioner examine him for any signs of medical complications. The Australian Government Department of Health and Aging Publications (2004) suggest that when dealing with chronic VSA, it is important for â€Å"mental state, organ and neurological examination, chest x-rays, blood tests and any additional tests that may be required to assess the presence of metabolic disturbances and morbidity to other organs such as the kidneys†(p. 142). SVA has been a serious problem in many remote Aboriginal communities and there are many rograms that have been put in place to help these Indigenous youth.The volatile substance abuse program (The Australian Indigenous Health Info Net, 2013) runs for 8 weeks offering residence to individuals participating in their programs. They also travel to remote communities to work with Indigenous youth who are having problems with petrol sniffing. Although these services would be great for youth in bigger communities with elder support, I feel that Samson would be more beneficial in attending compulsory treatment Wouth workers back petrol sniffing laws†, 2009) ue to his lack of family and elder support as well as his young age.By contrast If Samson did have the support of his brothers I feel that he would benefit from Cultural programs that would give him a sense of identity that teach him the ways of his ancestors by restoring the links to his traditional culture(MacLean& d'Abbs). Ethical Issues The first and foremost issue that would affect a counsellor working with Samson is their ability to be aware and respectful of any cultural differences or traditions.Westerman (2004) ,Vicary and Andrews (2001) McLennan and Khavarpour( 2004) ropose that due to non-indigenous health care workers being aware of cultural traditions and practices, many Indigenous Australians are wary of engaging in mental health services( as cited in Fan,2007). There is also the issue of gender roles in Indigenous culture, Fan(2007) also explains that it is common practice in health care to work with your same gender, so it may not be respectful for a female counsellor to work with Samson as he may feel shame, which may have a detrimental effect on his treatment and recovery process.As a counsellor there is also the ethical esponsibility of working with a minor, as Samson is only 14 years old. The Psychotherapy and Counselling Federation of Australia [PACFA] (2011) states that â€Å"Working with young people requires specific training, ethical awareness and competence. The practitioner is required to consider and assess the balance between young people's dependence on adults and carers and their progressive development towards acting independently' (p. 14). Therefore I feel that it would be advisable to refer Samson on to a culturally appropriate service that would be more equipped to help his needs.Conclusion In concluding this case study on a young 14 year old Indigenous Australian who is dependent on sniffing petrol we can see tha t Samson has built up a tolerance to the petrol and seems to need increased amounts of this substance in order to attain the desired level of intoxication. Petrol sniffing is a form of volatile solvent abuse [VSA] that is more common in disadvantaged or isolated communities which reflects the history of cultural oppression, poor health, unemployment, recreational opportunity and geographical isolation of remote Indigenous Australians.VSA can also cause the individual to nave violent outbursts towards other individuals as well as snowing signs of slurred speech, confusion and stupor which can lead to seizures, brain injury and death. The first step that would need to be taken in the process of treating medical complications. Cultural programs that would give Samson a sense of Cultural identity would benefit him greatly if he had support from his family but I feel that Samson would be more beneficial in attending a compulsory culturally appropriate service treatment due to the ethical issues surrounding his age.

Motivational Interviewing Essay

The Motivational Interviewing and Stages of Change approach is complementary to the cultural values of Native American people and emphasizes listening, learning, and respect. Addictions in this day and time can be contributed to many factors and effect every ethnicity of people. Substance addiction has even affected the smallest ethnicity of people, Native Americans since their encounter with white people. Motivational Interviewing (MI) has even helped Native Americans through counselors learning and implementing the techniques. Even though clients are naturally resistant to change, utilizing the three pillars are very effective in helping even Native American people because expressing empathy shows that you care and developing discrepancy between client’s present behaviors and values & beliefs. Counselors today need to be trained in MI and cross culturally trained also to better serve individuals. I would through MI be empathic and express it through reflective listening, paraphrase what I hear from the client, ask them let me see if I am hearing you correctly, You are saying†¦.., I would communicate respectfully with the client, be supportive and establish a non-judgmental therapeutic relationship with the client. There are some great CBT techniques alone with homework assignments to help deal with the shame and embarrassment that a client is feeling about their substance use or other problems that are going on. CBT can be self talk with positive statements to themselves, daily mood and thought record and etc. There are so many techniques that can be utilized with MI to help a client even through shame. As a counselor, I will utilize the following principles known also as pillars with MI to help motivate my clients: expressing empathy through reflective listening, developing discrepancy between client’s present behavior and values & beliefs, rolling with resistance by avoiding arguments & confrontation also adjust to the resistance, and last support self-efficacy by affirming clients strengths and allowing freedom and choice. First pillar that would be utilized is expressing empathy. Expressing empathy means to understand my client, know and respect where they are in the stage of change , and using reflective listening by using reflection, paraphrasing, or summarizing what has been stated by the client. For example, so let me get this right you said †¦Ã¢â‚¬ ¦.. , Did I get that right? Okay, let me see if I understand what you are feeling right now. In other words walk a mile in their moccasins and know where they are coming from. Second, pillar that would be used is developing discrepancy by getting the client to see that their behaviors that they are exhibiting does not reflect what they have stated that is their values, beliefs, and morals. I would listen to my clients, reflecting, and ask open ended-question. According to Capuzzi & Stauffer (2012), â€Å"When a client is able to experience an internal discrepancy between his or her current behaviors and his or her values, beliefs, and goals, the change process can begin. This is due in large part to the underlying principle of cognitive dissonance (p.131). Third pillar is rolling with resistance which is where a client is resistant to change than as a counselor I would not argue with the client, I will ask the client to tell me more about their view point so that I can understand where they are coming from more. Most important avoid labeling a client. I would ask open-ended questions to invite them in to talk more about what they believe is their reason for not wanting to change, engage in problem solving, or maybe reflecting back their values, beliefs, and goals (Capuzzi & Stauffer, 2012). Last pillar is support self-efficacy which is fostering the client’s belief that they can make the necessary changes successfully, making sure the client knows that they are responsible for deciding to change and carrying out the change, let the client know my belief that they can change, and guide client to explore alternative problem solving solutions or approaches to change (Capuzzi & Stauffer, 2012). In conclusion, I learned that if a counselor is trained in MI and understands how to deliver the techniques with clients that it would be an effective technique with clients to motivate the stage of changes. For instance, â€Å"data from the current survey collected in a Native American community suggest that MI may be well suited as an intervention to prevent underage drinking and that a MI research program to reduce underage drinking would be generally well tolerated in this reservation community (Tonigan, Miller, & Villanueva, 2007). References Capuzzi, D., & Stauffer, M. (Eds.). (2012). Foundations of addiction counseling (2nd ed.). Upper Saddle River, New Jersey: Pearson. Tonigan, J. S., Miller, W. R., & Villanueva, M. (2007). Response of native american clients to three treatment methods for alcohol dependence Retrieved from http://search.ebscohost.com.library.gcu.edu:2048/login.aspx?direct=true&AuthType=ip,url,cookie,uid&an=28650827&db=ehh&scope=site&site=ehost; http://xs6th8dt4r.search.serialssolutions.com.library.gcu.edu:2048?sid=CentralSearch:EDJ&genre=article&atitle=Response+of+Native+American+Clients+to+Three+Treatment+Methods+for+Alcohol+Dependence.&volume=6&issue=2&title=Journal+of+Ethnicity+in+Substance+Abuse&issn=1533-2640&date=2007-06-01&spage=41&aulast=Tonigan&aufirst=J

Character Development of Raskolnikov essays

Character Development of Raskolnikov essays Dostoevskys novel, Crime and Punishment, develops the character Rodion Romanych Raskolnikov as a criminal seeking redemption. The Marmelodov family came into his life and Raskolnikov, with goodness still in his heart, helped support them though a time of need. Sonya, the oldest daughter of this family, showed Raskolnikov that Jesus Christ could guide him in the right direction toward atonement for his sins. This journey to redemption brought Sonya and himself to love and care for each other. As Rodion Romanych sat on his couch envisioning his great accomplishments, identifying with Napoleon (Dostoyevsky 309), his financial situation forced him to drop from the University. In his stubbornness, he refused help from family and friends and became ill with monomania. He conjured up a theory that made his homicide a great triumph. At one point he became unpleasant because he was hiding his emotions from his peers so they would not find out about his crime. What is interesting was that his illness highlighted his emotions so much that his sickness was taken as madness. Thankfully he was not mad. He was simply so taken by his own delirium that all of his thoughts consumed his actions. Many months ago when Raskolnikov's theory was created he had been creating the pedestal, which would advance him as an extraordinary person. He slowly executed his plan by making contact with the person to be murdered and the scene of the murder. Sadly, he believed that if he used his intelligence, he would achieve a morally correct right to help mankind with a higher purpose. He used murder as a practical goal to help the needy ones. In this he acted selfish and pompous, thinking he was a Napoleon, a newly created savior. He would soon learn that man could not rely only on his own will, but on the will of God. His fantasy or justification for murdering the pawnbroker would be relinquished as the novel progresses. ...

New Generation of Mothers Essays

New Generation of Mothers Essays New Generation of Mothers Essay New Generation of Mothers Essay Ð  ousekeeper, provider of basic needs, etc. , largely determine the type of work men and women do. For example, given their traditional role as homemakers, more female than male workers tend to combine economic activities with household (non-economic) activities, to work intermittently over the year and to work closer to home, often even at home for pay or in a family enterprise for family profit.Furthermore, because of their assigned role as dependent members of the household, women tend to be relatively more active than men in non-market activities and in the informal sector; to be considered by others and even by themselves as economically inactive; to receive less education, and thus to be more confined in occupations requiring lower skills and paying less well; to be considered as secondary workers in their family enterprise even when they have equal responsibility; and, in times of economic downturn or structural adjustment, to be amongst the first dis missed from their paid jobs.In addition, women find it hard to break through the glass ceiling, which blocks their access to managerial or decision-making positions. Given structural constraints due to family responsibilities, women who are available and willing to work tend actively to seek work much less than men in the same situation and employers tend to be reluctant to employ women outside typically female occupations. Another area of gender differentiation is the allocation of resources and benefits among the members of a household.It has been observed, for example, that women who are self-employed have more limited access to production resources than men, which lowers their income (Loutfi, 2001). Furthermore, women do not necessarily have control over their use of the resources available to them, nor do they necessarily reap the full benefits accruing from their efforts. Women’s and men’s gender roles also determine their different needs and constraints.For example, the degree to which women actually participate in and contribute to the production process is highly dependent on their marital status, on whether they have small children, and on whether they have to care for other persons in their households. It is recommended that companies should strive to improve their policies regarding the work-family balance of the working mothers in their workforce. The government should also look into ways how to effectively legislate these policies so that working mothers will have more leeway as they take their shoes to assume several roles at home and at work.It is about time that opportunities and recognition should be truly bestowed to women. At their best, the growing number of working moms should be assisted when they want to attain their goals in workplace and at home. These cannot only relieve them with their multiple roles they possess, but these recommendations could help define, energize, reward, and expand their own lives as self-actualized individuals.Bailey, Maria T. Trillion-dollar Moms: Marketing to a New Generation of Mothers.Chicago, IL, USA: Dearborn Trade, A Kaplan Professional Company, 2005. B arnett, R. C. and Baruch, G. K. Women’s Involvement in Multiple roles and Psychological Distress, Journal of Personality and Social Psychology, 49, 1985: 135-45. Blackwelder, Julia Kirk. Now Hiring: The Feminization of Work in the United States, 1900-1995. 1st ed. College Station, TX: Texas AM University Press, 1997. Callahan, Daniel. Depopulation Bomb: A Crisis in Western Birthrates? Commonweal. 20. 132, (Nov 18, 2005):13-17.

Pronouncing the Spanish L

Pronouncing the Spanish L You may not have noticed, but the L in English has two sounds that are quite different from each other - and if you can remember that, you can easily learn the sound of the L in Spanish. The two L sounds occur in the word little - and the sound of the Spanish L is basically the same as the first L but not the second (a sound, by the way, that native Spanish speakers often find quite difficult). In other words, the Spanish L is always pronounced with the tongue at the front of the roof of the mouth similar to the L in words such as love and alike. It is never pronounced with the vowel-like sound found in words such as ball or cell. Phrases used by native speakers in our audio lesson on pronouncing the L are lo siento mucho, hola,  ¿quà © tal? and igualmente, gracias. The pronunciation of the L should not be confused with that of the LL, which used to be a separate letter of the alphabet.

Conduct an interview with an Informatics Professional Essay

Conduct an interview with an Informatics Professional - Essay Example Therefore, although companies differ in the way they use this term, CSO is increasingly used to refer to the highest ranked person responsible for the entire security of an organization, that is, both physical and digital (CSO, 2008). This paper, through interviewing a person working in this position, investigates the roles, responsibilities, qualifications, background, experience and challenges facing chief security officers. The telephone interview involved Mr. Anthony Gacanja who is the current CSO of Safaricom Kenya, a major network provider company in Kenya. Mr. Anthony Gacanja is currently the Chief Security Officer at Safaricom Kenya. He did his O level at St. Mary’s School Nairobi and holds a bachelor degree in Bsc. Electrical and Electronics Engineering (majoring in Telecommunication) from Nairobi University. Before joining Safaricom, he worked as a Manger of Technology Security and Risk Services in Ernst and Young and also as an Application Systems Developer at Software Technologies Limited. He has vast experience in IT consultancy and information systems assurance and audit. Besides holding a bachelor degree, Mr. Gacanja is also passed his exams both in Certified Information System Auditor (CISA) and Certified Information Security Manager (CISM). When asked about the main roles and responsibilities of a CSO, Mr. Gacanja said that a CSO has several duties and responsibilities depending on the company he or she is working with. However, although he accepted that these duties and responsibilities may vary from one organization to another, he points out a common aim for all CSOs is to ensure good security to an organization and work force. He gave the following as the main roles of any CSO in any organization: On qualification, Mr. Gacanja said that any individual who wishes to be a chief security officer must have a strong knowledge of security related concepts and excellent contacts

Using a range of company examples from global retailing, critically Essay

Using a range of company examples from global retailing, critically review the extent to which you think competitive advantage is due to the possession of unique resources - Essay Example Gaining competitive advantage by using the resources of the firm can include access to natural as well as other resources which can help organizations to stay ahead of the competition. This paper will discuss about four firms from retail industries and will discuss as to whether the competitive advantage possessed by each of the firm is based upon the unique resources possessed by them. By using different strategic frameworks and theories, this paper will focus upon how firms like Tesco, Carrefour, Wal-Mart and Aeon use their unique resources to gain competitive advantage and remain at the top of their industry. Frameworks and theories which will be used for analyzing the above thesis will range from Porter’s five forces model, Value Chain analysis, VRIO as well as Core Competences. By using these frameworks, this paper will analyze and explore as to how leading firms in retail industry has been able to use their unique resources to remain at the top of industry in which they are operating. Competitive Advantage is considered as the strategic advantage firms have over their competitors in the industry they operate. Achievement of a competitive advantage actually strengthens the position of a firm in the industry and business environment they operate. Competitive advantage theory suggests that businesses should produce and sell high end products and sell them at higher prices in the market. Michael Porter who outlined this theory suggested that organizations need to possess attributes or group of attributes which can actually distinguish them from others in the market. Competitive advantage is based upon the notion of resource based view which outlines that organizations can have certain resources which can actually distinguish from others in the industry. (Stalk, 1992) The resource based view suggests that firms possessing competitive advantage are primarily based upon the application of resources which are at the disposal of the firms. This

Forrest Gumps and Michael Herrs Depictions of the Vietnam War Essay

Forrest Gumps and Michael Herrs Depictions of the Vietnam War - Essay Example Forrest Grump and Michael Herr depict the Vietnam War in more or less the same way although the former portrays the events more lightly. Michael Herr who was a writer in his twenties was a correspondent for the Esquire Magazine. The two major operations covered in the book are the siege of KheSahn and recapture of Hue that was the old capital of Vietnam. He happens to meet many soldiers and other correspondents in the process of gathering information about their experiences. Herr favors field work over tasks at Saigon that is relatively safer but the reality of the matter is that all Vietnam is unsafe. The enemy dominates the atmosphere with sounds of explosions and mortar attacks and bombs that go off all over the city (Knopf para. 1). The Vietnam War reaches the peak during the Tet offensive that started in January 30th, 1968 and from which it was named. A short time before Tet, the operation of seizing KheSahn begins on 21st January and ends in April 1968. Herr got to Khe Sahn by mode of a helicopter which is the primary transportation mode in the time of war. Here he encounters two marines with whom he shares a bunker. The two are Mayhew and Day Tripper along with others. The author gives a description of how the North Vietnamese Army besieges the base and digs ditches in preparation for a big operation. Everybody expects them to make a huge assault after they probe the fence regularly at night and marines shoot flares that are mortar-fired. The NVA, however, surprises by leaving the area quickly after the airstrikes take a bigger toll than anticipated (Knopf para. 2). Herr tells stories of the marines some of which are bizarre and others very touching. He portrays a deep sense of admiration for the troops that are fighting a dangerous war in a dangerous country. He also portrays the propaganda happening in the country but this time with less admiration.

Cultural Controversy Essay Example | Topics and Well Written Essays - 500 words

Cultural Controversy - Essay Example The long and short-term effects it has on girls mental, physical and reproductive health renders the term circumcision inapplicable. Furthermore, the process is considered an abuse of human and more so children rights since it is often performed on young girls (World Health Organization). While the proponents insist, the term Female Genital is meant to dehumanize it, the truth is; the term describes it and any objective description of the torturers process is enough to dehumanize it. It is most prevalent in sub Saharan Africa especially among the Somali culture and several others, North, East and horn of Africa communities especially Somalia and Ethiopia (Reymond, et al n.d). In the United Kingdom, girls fall also victim to this senseless ritual, during the summer holiday, which is the longest for schoolchildren. Many girls of African descent, as young as five are sent off to Somalia and elsewhere they are put through this scaring process (Foreign and Commonwealth Office). The tools used are often not sterile, and the resulting wounds can result in fatalities especially when it is done in Africa by illiterate old women trying to uphold â€Å"culture.† It also poses a significant risk of complication during childbirth; this is evidenced by the fact that infant mortality rates are often notably higher in countries that are known to practice FGM. Besides, the removal of the clitoris ensures they can never hope to enjoy sex in posterity. Ultimately, FGM is an extremely painful and inhuman procedure that no girl should have ever to undergo and in most countries, even in Africa it has been outlawed and is only done in

Management as a Regulated Profession Essay Example | Topics and Well Written Essays - 3500 words

Management as a Regulated Profession - Essay Example The introduction of strict legislative texts, like the Sarbanes-Oxley Act in the USA, has been proved to be an initial measure for the limitation of fraud in modern organizations (Heier et al., 2005, p.39). In the internal organizational environment, the ability of a firm to prevent fraud is depended on the level of cooperation/ coordination among employees at different levels of the organizational hierarchy. Under these terms, the human resources systems used within a specific organization are considered to be crucial for the success of the organizational initiatives against fraud. It should be noted that the effects of internal fraud on business performance can be differentiated in accordance with the nature of business operations, the business structure and the aims/ objectives of each organization; different assumptions are made in the literature regarding the effects of internal fraud on organizational performance; different plans of action can be suggested for mitigating fraud in firms that operate in various industrial sectors. Greenlee et al. (2007) focus on the relationship between the internal fraud and the type of organizational structure – the emphasis is given on non-profit organizations where ‘the losses due to fraudulent activities can directly reduce resources available to address tax-exempt purposes’ (Greenlee eta, 2007, 676). On the other hand, Levi (2008) notes that the expansion of global crime has been rapid due to the increased ability of ‘would-be perpetrators to recognize and act on specific opportunities’ (Levi, 2008, p.389). From another point of view, the external organizational environment is likely to affect a firm’s ability to control crime – the specific view is supported by Tilley et al. (2008) who emphasize on the difficulty to control crime in organizations that operate in ‘high crime neighbourhoods’ (Tilley et al., 2008, 443).  

Monique and the Mango Rains Essay Example | Topics and Well Written Essays - 750 words

Monique and the Mango Rains - Essay Example The town lacks running water in taps, trained doctors, have inadequate food, water and most people suffer from malaria, intestinal parasites and HIV aids. The book contains different instances of in equality, which occurs in marriage, family, economy, labor division and sexuality among others (Holloway & Bidwell, 2007). Gender inequality and social stratification from an anthropological perspective This refers to the classification method that groups sexes differently and it views women to be unequal in power, resources that they own, prestige and presumed worth. In this book, the author realizes dissimilar issues of gender inequality during her stay in Mali. There is gendered inequality in women whereby they face discernments in different areas thus lacking good opportunities to improve their status. Women face gender inequalities in health facilities while complying with their traditional role of child bearing hence seeking for assistance from traditional birth entourages. This bir th giving method endangered Malian Manianka women as they stayed in labor pain for a very long period and the midwife had no painkillers to relieve the pain. Based on diminishing health facilities that assist women while giving birth, most of them suffered from genital ablation while still in their childhood stages. The inequality that existed among the Malian Manianka women caused too many losses. This is because one in every twelve women died while giving birth and one in every fifteen children died at birth. The town also had rape instances, whereby Monique tells that her first sex experience was through rape (Holloway & Bidwell, 2007). The book illustrates a high rate of inequality in the marriages among people of Malian Manianka, because women do not get married willingly and they lack satisfaction. According to the author, women faced many problems generating from their communities. Women of this town had no permission to decide when to get married; instead, their parents forc ed them at a very young age. After getting married, women gave birth to many children, and they were banned from using contraceptives, which made Mali a very populated country in Africa. Marriages had gender violence mainly to those women that failed to accomplish their traditional role of child bearing. In this village, immediately after a woman gives birth, she only stays for few hours and resumes to her normal roles. This shows how men in Malian Manianka are not concerned with their marriages by not carrying on the women’s duties after birth to allow them recover. There is inequality among families in this town because no one has permission to choose his/her preferred family; instead, the community chooses for them. Monique the midwife is an example of such family whereby her marriage resulted from the cultural practice of choosing husbands. This resulted to infidelity in her marriage as Monique had an affair with Pascal the man that she loved in order to get satisfaction. Franois husband to Monique failed to meet his parental responsibilities by not providing his family with basic needs (Holloway & Bidwell, 2007). Instances of gender in equality in this book are also common to families. This is because most women in the book are unhappy in their marriages, but they cannot divorce their

Management as a Regulated Profession Essay Example | Topics and Well Written Essays - 3500 words

Management as a Regulated Profession - Essay Example The introduction of strict legislative texts, like the Sarbanes-Oxley Act in the USA, has been proved to be an initial measure for the limitation of fraud in modern organizations (Heier et al., 2005, p.39). In the internal organizational environment, the ability of a firm to prevent fraud is depended on the level of cooperation/ coordination among employees at different levels of the organizational hierarchy. Under these terms, the human resources systems used within a specific organization are considered to be crucial for the success of the organizational initiatives against fraud. It should be noted that the effects of internal fraud on business performance can be differentiated in accordance with the nature of business operations, the business structure and the aims/ objectives of each organization; different assumptions are made in the literature regarding the effects of internal fraud on organizational performance; different plans of action can be suggested for mitigating fraud in firms that operate in various industrial sectors. Greenlee et al. (2007) focus on the relationship between the internal fraud and the type of organizational structure – the emphasis is given on non-profit organizations where ‘the losses due to fraudulent activities can directly reduce resources available to address tax-exempt purposes’ (Greenlee eta, 2007, 676). On the other hand, Levi (2008) notes that the expansion of global crime has been rapid due to the increased ability of ‘would-be perpetrators to recognize and act on specific opportunities’ (Levi, 2008, p.389). From another point of view, the external organizational environment is likely to affect a firm’s ability to control crime – the specific view is supported by Tilley et al. (2008) who emphasize on the difficulty to control crime in organizations that operate in ‘high crime neighbourhoods’ (Tilley et al., 2008, 443).  

Gang Violence and Juvenile Delinquency Research Paper

Gang Violence and Juvenile Delinquency - Research Paper Example According to the Finley (2007), cultural and social landscape has varied significantly since the establishment of the juvenile system in the early 1990s. In essence, gangs, drugs and easy accessibility to deadly weapons have contributed majorly to the increasing number of juvenile crimes including murder which currently has reached an alarming rate. They further claim that juvenile court system has insufficient resources to handle amicably the problems brought by amoral teenagers and children in the society. Rosenheim (2002) explains that the perceived clemency associated with the juvenile justice system as prescribed by the juvenile laws insinuate that it is not within the context of law for the juvenile court judge to warrant any form of punishment for the young criminal but to issue rehabilitation assistance to the juvenile. This has highly contributed to the juvenile system lack of capacity of correcting the amoral behavior fostered by the young but violent children. The system b ased on the current situation juvenile law stimulates a rotating-door course that leads the message that juvenile criminals are not held responsible for their wrong doings and not until these offenders are subjected to adults criminal courts that when they experience punishment for the first time in their lives. Based on my analysis, the law should be revised to allow for the punishing of the juveniles criminals in the first instance as this would prevent future amoral activities when the juvenile offender shall have grown into adult. In addition, accordance with the juvenile law, it is prohibited to release the juvenile criminal perpetrators from the authority of the juvenile court at an age above eighteen years. Serving less years in juvenile jail for an offense which would have earned an adult ten or more years sentence is unjust. For effective operation and success of this system, punishment for the misconduct should be the same irrespective of the age of the offender (Whitehead and Steven, 2006). Owing to these inadequacies and problems associated with juvenile laws, many critics have proposed for its complete overhaul or amendment of some of its laws, failure of which the crime rate among the young perpetrators would continue to escalate in the society. According to Scott and Steinberg (2008) some of these mitigation measures are juveniles should have complete DUEPROCESS rights such as right to trial by jury in the same way adult criminals are tried, freedom from the rehabilitation ideology associated with the juvenile system, allowing the juvenile to be tried to court once the young perpetrators are convicted and letting the juveniles to be accountable for their amoral actions. Theories of Delinquency Causation According to Banduras social theory, people acquire knowledge via observing others’ attitudes, behavior and results of those behaviors. Based on this theory, majority of human conduct is learned through observation and modeling. This infer s that through observing how others conduct themselves, one comes up with the idea of how newly acquired behaviors are carried out and eventually this explicit information works as a blueprint

Studying Management Information System Of Starbucks Information Technology Essay

Studying Management Information System Of Starbucks Information Technology Essay In this thrilling subject, i would be focusing on the Management Information System of Starbucks. It is no doubt that this firm in question, is one popular and well patronised firm amongst many. That being said, i would be doing justice to the very background of this organization in question and i would elucidate in tangible details their IT systems, schemes and practices and lastly, i would be recommending what i see fit to suite the organisation even in this era of technology. But before i proceed, i would like to briefly define MIS(Management Information System) MIS (Management Information System) This may be defined as a general word for computer systems in an enterprise or organisation which provides information or details on firms business operations. Its also refers to the people who manage and maintain these systems. Furthermore, in a large corporation, MIS or the MIS department refers to a central or centrally-coordinated system of pc expertise and management, and entire network of computer resources in a business organization (firm). Starbucks was first introduced in Seattles Pike Place Market in 1971. Back then, the company was called Starbucks Coffee, Tea ans Spices before change into what we have known today, Starbucks Coffee Company. Today, there are approximately 16, 706 Starbucks stores in 50 countries. The first ever Srabucks store in Malaysia opened on December 1998, located at KL Plaza, Jalan Bukit Bintang, Kuala Lumpur. Later, there are more than 115 Starbacks stores in Malaysia.Basically, their buyers will travel to Africa, Asia and Latin America to choose only the best quality of arabica beans. These high quality beans will be sent for roasting and production. Starbucks experts then only combine the roasted beans with Italian style expresso beverages to produce different type of cold and hot coffee beverages. The famous products introduced by Starbucks company and mainly can be found in all of its stores include more than 30 blends single-origin premier arabica coffees. As for their own signature of handcrafted beverages such as hot and iced expresso beverage, coffee and non-coffee blended beverages Vivanno smoothies, Frappuccino bottled coffee or blended and premium ice creams with the and brewed coffee and also tea product,Tazo Tea. Merchandises are also offered by Starbucks are coffee mugs and accessories. Customers not only can enjoy sipping their high quality coffee beverage but also indulging on baked pastries, sandwiches and cakes. The company focuses in providing a relax, comfortable atmosphere with modern fittings. It is an ideal place for hanging out with friends and families, with entertainment magazines to read. Most of the Starbucks company offer free wi-fi for their customers, so it is a great advantage to business people discussing on their work or students doing some research for assignments/ projects. POS P.O.S which stands for Point of Sale is a front-of-the-house system use by Starbucks company. Only employees with given authorization can access to this system such as Assistant Manager, Shift Supervisor, and Store Manager. Types of transactions can be made by the manager include paid in, paid out in the cases of emergencies or using the cash to buy supplies needed by the store. Other than that, making amendments for transaction mistakes in a form of refund. Important for inventory control as well. List of all food and beverages and merchandise sold are recorded in the P.O.S system. Wastage cost might as well be stored. All these vital information of dailys operation are transferred to a Management Work Station system to be analysed and evaluated. The information will be transform into a measurable data for decision making purposes. Manager Work Station (MWS) Manager Work station is the back of house computer system which prepares and sends all store information to adequately manage all parts of the store business. It brings access to real-time system wide reporting at store level. It shows all the various functions provided on the Intelligent Restaurant Information System (IRIS), of which some are only usable by partners with the accurate security. It helps the store manager to manage the store and also help the franchisees manage their entire market chain. It can be used in the office where there is a pc connected to an intranet of which is a private link channel for staffs to use the organization network that resembles the internet. It is required to log on with a passkey and ID to use the system. The system detects security level and allows using the method assigned to the security level. The staff can only use the time button option, which is a method that saves staff clock in and out for lunch and shifts. A begining of day and end of day is also saved into the very system on a daily bases. Shift managers can use cash control methods that are used to count cashboxes, change or fix transactions and to make ready everyday bank deposit. A menu of available reports is provided on a report menu. The Store manager can use these reports to follow sales, check customer transactions within various hours range, to view sale by product category, to save wastage, to carry finance audit. All these informations are relevant to Store Managers for them to pin out business requirements and customer needs, to check peak time in the store, to maximize or change product ordering, to manage wastage and monitor stock and choose whether it is necessary to reduce labour. Managers can use staff information and personal records in the work station, they can place new partners, cut off partners, manage employee records, watch employees training and process payroll. The payroll process carries over details to the support centre in order to pay partners. Store Manager and the shift supervisors can use the IRIS System to process electronic ordering for food, stationery, packaging. Hardware Example of hardware used for the computer system in Starbucks company include ISDN (Integrated Services Digital Network) modem and speed touch cable modem. These two are connect the Starbucks computer system to its retail network system. Wireless internet connection by T-mobile allows consumers to have the access of the available wireless network. Cisco Wireless and Cisco Routers are the type of equipment used as well. Other hardware output devices used include printers to process receipts. For security purposes, chips and pins for the payment made by credit card or debit card. A confidential security number (Pin number ) is required when making payment by either of these two cards. No signing is required. Further more, the Starbucks firm, uses Intel based systems and fast Computers. In terms of functionality, the Starbucks firm is bent on getting hardwares(PC) that have great and outstanding specifications to avoid slow down on business. A sample spec would be: A PC with 512 Memory or 1GB. And A flat screen monitor and processor speed of 2.40GHZ and a HDD of 150GB to 200GB. The company has a nac for greater heights that why its no surprise that Starbucks is doing greatly well in terms of their ability to maintain their standards. Software OS (Operating System): As we all know, the I.T age is springing forth with lots of softwares and technology all with the focus of improving the lives of humans in all ramification of life. Having said that, the Starbucks company makes use of Windows based softwares for their computers which is categorized in the hardware section. They run applications that aid their business. Example POS, Excel and others. Excel is often used for their spreadsheet needs. When it comes to system software for driving their hardwares, they run windows XP or 7. Current themes and practices This Starbucks new idea of POS was introduced earlier this year and only available in all 6,800 Starbucks stores in the United States. This process only applicable to consumers with Blackberry or iPhone. The first steps will require consumers to download the Starbucks Card Mobile Application to their phones. Once he / she enters their registered Starbucks gift cards number into their phone and when they obtained the application, the card number is automatically saved. Consumer upon arriving at Starbucks counter can just inform the employee to make payments for their order via mobile phone. He / she then opens up the Starbucks Card Mobile Applications, choose the payment screen in the application where the 2D bar code appear showing the consumers Starbucks card. When this process is completed, Starbucks employee will key in payments made by mobile phone in the P.O.S system and asked the consumer to place their phones under the customer facing imager for scanning. The 2D bar-code is de tected and treated the transactions in the likes of a giftcard, based on the normal payment verification procedures. Consumer can just enjoy their coffee once the transaction is done. However, there are some setbacks of this new P.O.S strategy implemented by Starbucks. First, not all retailers practice the use of stored value card or known as giftcard. Secondly, Starbucks focuses on potential users with key smart phones, such as iPhone and Blackberry. It only covers the consumer demographic of savvy consumers at the U.S where most the people are iPhones and Blackberry users compared to consumers in Malaysia. Not all Starbuckss mobile payments scheme is negative since this methods of payment can actually help Starbucks to cover up the cost of operational system, able to record loyalty data of consumers and balance of cash as well. Since payments are charged on the consumers giftcard, means that the 2D bar-code payment system is actually connected to the card. Besides, payment made th is way is different compared to the legislation for payment made by credit card or debit card . Evaluation: 4).Starbucks also runs a high scale of management in handling their I.T related issues. They are I.T aware such that, they have good network services. An example would be, Starbucks offers free WIFI Zone. An attraction for a customer on the move. The firm has VOIP services for communication with other chains around the globe. As we live in a net centric age, Starbucks has made it a perfect fit, to incorporate most I.T business related schemes into their business. A good analyses on this company, would however show us that Starbucks uses the I.T based things to build their customer range. It is however no secret that most competitors have based their examples on companies in the likes of Starbucks. Some practices in Starbucks, include some discount sales issued by the management. A customer however sees this as a grand opportunity to have a 50%(Percent) discount on whatever he buys and also enjoys free internet. This indeed is a wise practice. The ManagementInformation system has in many ways, made things easy for staffs. Most messages to staffs are communicated via the network. As fore mentioned, Starbucks uses intranets and internet(Voip). This helps in forwarding swift messages to workers in the company. In addition to the newest development of MIS, payments made via mobile phones currently introduced in the Unites States is also one of the best P.O.S strategies to reduce the cost of operation. This company also makes judicious use of their MIS by running web based adverts and all. The firm keeps its customers continuously aware of products and new recipes that might be tried in a given time. Thus, their market base increases undoubtedly. Marketing Analysis: Retails: Recommendation: In my opinion having patronised Starbucks from time to time, i would suggest the following: Starbucks should try in purchasing a reasonably fast internet with low traffic. They should try to maintain their hardwares and try upgrades from time to time, to avoid being left out in the dark age of slow computing. They should employ staffs that are more I.T learned to avoid difficulty in system operations. They should embrace more of touch screen services. And what i mean is, buying gadgets(hardwares) that provide self service for each customer. The MIS should continually see to it that customers are intrigued by the brilliant I.T based services that Starbucks provide thus leaving the customers spell bound to return and purchase more items . They could also provide on screen advertisements for new generation hardwares this in itself, could be an avenue for Starbucks to get paid for advertising for I.T firms in the cities and wherever . They could also make a web based system, that would enable customers to order online to ease driving out of the office at lunch. Conclusion: At this juncture, it is important that i reiterate that it is of immense importance that the MIS in Starbucks embraces more heightened technology hardwares to ease the work load and the number of staffs. We all in the world are aware of the generation of computers. This promises to be huge and phenomenal turn in every industry especially industries like Starbucks. As we see Managements improve their information systems, it would be an important part for Starbucks to play in their MIS. With an improved and well balanced MIS, Starbucks has what it takes to battle up for the future even competitors. Time is of the essence for firms like Starbucks this is because each day slips away and more upgrades are made to databases. To this end, i would beseech Starbucks, to keep up the very good work and embrace a new era of improved management systems. Thus increasing their profit base and client base.

Spiritual Insights in Daniel Defoes Robinson Crusoe :: Robinson Crusoe Essays

Crusoe’s Spiritual Insights Robinson Crusoe by Daniel Defoe is considered to be the first novel of incident. Before I read the novel I knew something about poor Robinson Crusoe--shipwrecked on a desert island, lived on the island for a lot of years, and acquired a friend by the name of Friday. As I began to read, I had the preconceived notion that Robinson Crusoe was just an adventure book. However, I read no more than a few pages before my mind was greatly enlightened. Robinson Crusoe does not suffer just one shipwreck, but two of them. He is captured by Moorish pirates, escapes, and goes to Brazil to become a planter. After his second shipwreck, Crusoe gives details about his techniques for survival. Also, the ending of the novel is quite surprising with a setting that is quite a contrast to the desert island. Arguably, one of the funniest scenes in all of literature is recorded in the final chapters. If the book is not holding the reader's attention because of the suspense, then it is held by the profound spiritual insight that Defoe includes within the pages of his work. This was the biggest surprise to me of all. For example, in chapter 12, Robinson Crusoe states: "From this moment I began to conclude in my mind that it is possible for me to be more happy in this forsaken solitary condition, that it was probable I should ever have been in any other particular state in the world, and with this thought I was going to give thanks to God for bringing me to this place." Crusoe was convinced that the reason for all of his calamities was the result of his disobeying the counsel of his father. The theological discussions with Friday are wonderful. Indeed, every Christian can relate to Crusoe's wrestling with faith and fear. I finished the book with the conclusion that this book should be standard reading for every Christian, particularly preachers. Preachers will find a wealth of sermon illustrations in Robinson Crusoe. So, why is Robinson Crusoe so sadly neglected among Christians when it is obvious that the book is a Christian classic? No doubt, abridged versions of the novel removes the incentive for readers to read the actual work. Many people have read a children's version of the novel or worst yet, they "have seen the movie.

Prayer In Public Schools :: Religion in Public Schools

Should a Catholic school be reimbursed by the state for school supplies? Should there be time set aside in school for kids to pray? These are some of the many questions the U.S. Supreme Court asks themselves when they are confronted with cases involving religion in school. Although there are some sound supporting arguments for prayer in school, the opposing arguments more than justify the non-religious atmosphere of public school. Supporting arguments for In School Prayer have little validity. For instance one argument is that the framers of the constitution were religious, so they didn’t mean to prohibit all government sponsored prayer or acknowledgment of â€Å"GOD.† This is assuming one way just to be in favor of the In School Prayer idea. Pro-Prayer activists also believe that it is VERY important for the nation’s children to have religious values instilled in them. I strongly disagree with this statement solely because they are assuming that someone without a religion has lower or no values as compared to a religious person. Valid arguments on this side of the issue are rare, but they do exist. One example is that in public polls, seventy-eight percent of the nations thinks prayer in public schools is a good idea. This logical at first, but the truth is many polls convey the notion that voluntary prayer before, after, and during school is forbidden. Another argument addresses the fact that religion is already everywhere anyway. It is on our currency, our leaders are sworn into office with reference to â€Å"GOD,† and our flag salute also contains religious statements. These are good points to address, however, I believe they are wrong as well. †Two wrongs don’t make a right.† Opposing arguments are a lot more convincing than the supporting points. First of all, students have the right to conduct religious practices on school property, so there is no need to set aside specific time in the curriculum

Diverse Racial Experience Essay

The chapter by Ruth Frankenberg entitled, â€Å"Introduction: Points of Origin, Points of Departure†, argues that the way one is perceived in society drastically changes their experience and advantage over others. Therefore, white women are often distinguished by their whiteness which gives them a more diverse racial experience (Frankenberg, 1993, pp. 1). With being white comes various additional components that set it apart from the other raced women of the world. Moreover, being a white woman automatically links them to a more favourable position of superiority in the way that they are often identified. This means that they get certain benefits by being white, as colonialism positioned them to have a large portion of control and authority over others. This provides them with the advantage to define the public and its individual beings the way they believe or want it to be. Moreover, they see their whiteness as a normative position in society that is invisible. Frankenberg`s goal is to make whiteness visible so that a white person can identify that they have an advantage over a person of colour by virtue of their skin. She also takes into consideration the intersectionality of class, culture, ethnicity, gender, and sexuality in a white racialized body (Frankenberg, 1993, pp. 1). Colonization is an important factor to Frankenberg because of how it uncovers the concept of whiteness and how it subsequently became associated to a position of authority and power. In the article `The Murder of Pamela George`, the author observes that history of colonial violence permitted white men to annex land that did not belong to them and treat it as though they were entitled to it (Razack, 2004 ,pp.127). This perception has perpetuated the control and authority of white people throughout history. A critique in the second wave of feminism made white feminists reconsider what and for whom they were advocating. The movement of feminism was envisioned to include all women but it only targeted one specific group of white middle class women. This occurred because the women could only see there suffering from their particular standpoint. This is seen in the article â€Å"The Problem That Has No Nameâ€Å" by Betty Friedan since she assumes that all women are homogeneous and all have the same lived experiences. She does not consider race, class, and sexuality as a factor in feminism (1997). White women mostly consider their whiteness as undetectable and thus not subject to racism (Frankenberg, 1993, pp. 3). These white feminists in the second wave were unintentionally being racist towards other women; this made them unsure about how to precede and resolve this issue (Frankenberg, 1993, pp. 4). Frankenberg educated herself about racism by positioning herself to learn from the standpoint of women of colour. Enakshi Dua stated in her article that, in order to understand how race and gender are interconnected one has to listen to the lived experiences of women of colour (2005, pp. 64). Frankenberg followed this method formulating questions that she wanted to investigate to find out how racism affects a white women`s life and how society propagates racism through societal means. After answering these questions Frankenberg proceeded to figure out how white women can fight against racism. Most white women believe that their race is invisible and do not realize that it gives them a distinct experience in the world. This is because the dominant class structures society and thus normalizes whiteness. White women and women of colour have distinct experiences that are subject to how they experience racism. Whiteness is socially constructed and it does affect a white women`s life. However, white women usually tended to regard racism as something that has no effect on them and that women of colour only have to live through (Frankenberg, 1993, pp. 6). This belief does not put the onus on the white people and it does not identify the perpetrator of the subjection. Racism does not just happen, it is constructed (Tim Wise 2005). Therefore, it impacts the lives of white women which makes race and gender intersectional for all women not just women of colour. There is a denial in the observations that there is one specific dominating male gender. There is also an abundance of only white women`s experiences by this masculine hegemon. After women realized that the world view did not only have to be seen on a male standpoint the world started to shift views (Frankenberg, 1993, pp. 8). Women of colour now want to focus on a standpoint from a radicalized point of view in order to stop racism. Moreover, since white people are the oppressors they cannot see how their situation is reinforcing racism. People of colour are the oppressed and know exactly how they are underprivileged. Subsequently, women of colour were the first to see how gender, race and class forms a persons experience in life (Frankenberg, 1993, pp. 8). White women did not see their race as something that was constructed. They did not see themselves as racialized because they were coming from a position of privilege. This position for a white person was normalized throughout American history. Therefore, in order to deconstruct race white women have to admit it is something that affects them (Frankenberg, 1993, pp. 11). Race is in a fluid motion and changes constantly with society because it is an economic and political construct. Historically, the white dominance was vindicated because of false biological account that white people were superior (Frankenberg, 1993, pp. 13). This biology justified colonization as well as the enslavement of people of colour that soon followed. The justification shifted to culture as the reason that made people inferior and if they integrated with American culture they would achieve success on merit like white people. However, this belief kept blaming people of colour for their position in society.People of colour were first seen as different from white people, then there was an embrace of colour blindness, and finally people realized that they needed to be able to see the differences in society so they can explain them. This last movement’s purpose was to make people aware of race; this was led by the people of colour themselves. They did not want to be invisible because there situation was not improving because people were ignoring the underlying problem. The racialization of people of colour and white people was constructed with colonization. The European culture was embedded into the way the United States constructed its country. This constructed whiteness as belonging and being a person of colour as an outsider (Dua 2005, pp. 60). The dominant western culture –which was white- positioned itself to dominant over the other races. This created the standard citizen that belonged and made people of colour not included in the so called superior western culture. Frankenberg`s argument illuminates how the dominant class rationalized whiteness as not being racialized. Colonization formed the dominant race and reproduced it through society. By normalizing whiteness the white people did not need to consider how it benefited them and subsequently how it negatively affected people of colour. By naming whiteness, Frankenberg will be able to pinpoint how that perception can change so that people can be equal even with there differences. In conclusion, by admitting that white people are racialized will assist anti-racist feminists in their mission to stop the racialization of all people. This would stop white people from believing that they are the only ones that belong in North America and eventually create a system based on meritocracy rather then privilege by virtue of a persons skin.